Manchester City goalkeeper Ederson and star midfielder Kevin de Bruyne were both substituted on Tuesday with injuries.
Ederson was caught by Cristian Romero in the second half and for a moment looked in serious pain while receiving treatment on the pitch, but Guardiola later confirmed the Brazilian was not concussed.
“He had a problem with his eye, he could not see properly so the doctor said I should change,” he added.
Ederson was unhappy when he was substituted, kicking a cool box on the sideline, although replacement keeper Stefan Ortega did superbly to keep out a one-on-one chance from Spurs captain Son Heung-min after coming on.
Guardiola said that De Bruyne picked up an ankle injury.