Manchester United midfielder Kobbie Mainoo will be out for a “few weeks” with a muscle injury.
The 19-year-old England international suffered the problem during United’s 0-0 Premier League draw at Aston Villa and subsequently withdrew from the Three Lions squad for their two Nations League games last week.
Defender Harry Maguire has also been ruled out for a similar timescale after also picking up an injury at Villa Park.
However, Noussair Mazraoui has returned to training following a recent medical procedure after suffering heart palpitations.
The Morocco international underwent a precautionary, minor corrective procedure to rectify a relatively common condition last week.
Midfielder Manuel Ugarte undertook a recovery session on Thursday after limping off in Uruguay’s goalless World Cup qualifying draw against Ecuador on Tuesday.
Alejandro Garnacho (knee) and Amad Diallo (illness) were also back in training after missing games for Argentina and Ivory Coast respectively, and look set to be involved when United welcome Brentford to Old Trafford on Saturday.
Mason Mount and Luke Shaw remain sidelined, while Tyrell Malacia continues to progress towards full fitness after a long-term knee injury.