Sabalenka, who reached the last four at Roland Garros in 2023, has made at least the semi-finals at each of her past six Grand Slams.
The 26-year-old Belarusian combined trademark power with measured drop shots as she produced 27 winners in recording an efficient win over her 83rd-ranked opponent.
Having begun the year by successfully defending her Australian Open title, Sabalenka prepared for the French Open by reaching the final in the clay at both the Madrid Open and the Italian Open.
On both occasions Sabalenka lost out to world number one Iga Swiatek, who had to save a match point as she overcame Naomi Osaka in a three-set thriller on Wednesday.
Meanwhile, Danielle Collins’ final French Open came to an end as she suffered a surprise defeat by world number 125 Olga Danilovic of Serbia
The American 11th seed, who plans to retire at the end of the season, lost 6-7 (3-7) 7-5 6-4.
Ukraine’s 15th seed Elina Svitolina progressed with a 6-4 7-6 (7-3) victory over French home hope Diane Parry, while 14th seed Madison Keys claimed a 6-0 7-6 (9-7) win against Egypt’s Mayar Sherif.
Reigning Wimbledon champion Marketa Vondrousova fought back in a rain-disrupted display against American Katie Volynets, winning 0-6 6-1 6-4.