Earlier, the women’s race was held up for an hour and shortened, after an accident involving a police motorbike escorting the peloton.
During a sprint finish in Berg en Terblijt, Wiebes raised her arms a few metres short of the line to celebrate, which allowed Vos to lunge forward to snatch victory from her Dutch compatriot.
This is the 36-year-old’s second victory in the women’s race, which returned in 2017 having previously been staged from 2001-2003, while Wiebes, 25, has yet to win it.
A policeman “was injured following a collision with a car on the Bergseweg while supervising the Amstel Gold Race”, the Limburg police said on X.
The race was held over a shortened route that avoided the crash site, with Vos – who rides for Visma-Lease a Bike – exploiting the error by SD Worx’s Wiebes to win the sprint, while Britain’s Pfeiffer Georgi was fourth behind third-placed Norwegian Ingvild Gaskjenn.